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Temporal plots of major renal metabolites (peach), transcripts (yellow), and proteins (green) involved in NAD + metabolism detected in renal transcriptomic, proteomic or metabolomic data sets in control (Ctrl) and cKOt mice

& Morgan, J

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After such screening, trimetazidine was identified as the most promising candidate to treat bipolar depression because it is novel in psychiatry, has an excellent safety profile, and crosses the bloodbrain barrier